Visual Studio is shipped with hundreds of keyboard shortcuts. Here are my favorites:

General:

• Go to Definition: F12
• Find all References: Shift + F12
• Go to last edited position in code: Ctrl – -  (Ctrl – Dash)
• Delete Line: Ctrl – L
• Cut Line: Shift – Del
• Copy Line: Ctrl – C (no need to select the text before)
• Comment/Uncomment: Ctrl – K – C / Ctrl – K – U
• Insert Snippet: Ctrl – K – X
• Surround with Snippet: Ctrl – K – S (mark selection to be surrounded first)
• Full Screen: Shift – Alt – Enter

Debugging:

• Show Immediate Window: Ctrl – Alt – I
• Run to Cursor: Ctrl – F10
• Toggle Halt on Exceptions: Ctrl – D – E